LC-MS Solvents from Agilent

Agilent InfinityLab LC-MS grade solvents have been developed for optimum performance with Agilent LC instruments and applications.

All solvents are manufactured to a high purity level, and are tested and specified for MS applications. The lowest levels of trace metal impurities and low acidity and alkalinity properties help achieve excellent detection limits for mass spectrometry, extend column lifetimes due to reduced contaminants, and minimise ghost peaks in gradient runs. 

To protect your system from contaminants and clogging, LC-MS solvents are pre-filtered through a 0.2 µm filter. There is no need to filter separately, unlike lower quality chromatography solvents – the solvents are ready to use.  Benefits include reduced troubleshooting and instrument downtime caused by impure solvents. 

Agilent LC-MS solvents are easy to use, and offer excellent lot-to-lot reproducibility, ensuring consistent results. Batch specific certificates of analysis are also available to meet GLP specific requirements.

Agilent offers LC-MS grade acetonitrile, methanol and water solvents, which are widely used in reversed phase HPLC applications.

 

 

Part Number Product Description Price Qty
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Features

  • Minimises background noise and reduces ion suppression
  • Pre-filtered at 0.2 μm to safeguard your system from contaminants and clogging
  • Maintains ultra low impurity levels to minimise ghost peaks in gradient runs
  • Improves column and capillary lifespan, promoting cost efficiency
  • Excellent lot-to-lot reproducibility ensures consistent results
  • Designed and optimised for seamless integration with Agilent instruments
  • Shipped in clear borosilicate glass bottles

LC-MS Acetonitrile:

  • Synonyms: Cyanomethane, methyl cyanide, ACN, ethyl nitrile
  • Formula: CH3CN
  • CAS number: 75-05-8
  • Molecular weight: 41.05 g/mol

LC-MS Methanol:

  • Synonym: Methyl alcohol
  • Formula: CH3OH
  • CAS number: 67-56-1
  • Molecular weight: 32.04 g/mol

LC-MS Water:

  • Synonym: De-ionised water
  • Formula: H2O
  • CAS number: 7732-18-5
  • Molecular weight: 18.02 g/mol

Specification

The ultralow impurity contamination levels highlighted in these specifications for Agilent’s LC-MS grade solvents makes them the ideal choice for all Agilent LC-MS instruments.

 

LC-MS Acetonitrile Specifications:

Identity (by Infrared Spectroscopy): Identity confirmed Al (Aluminium): ≤ 5 ppb
Purity (by Gas Chromatography): ≥ 99.9% Ca (Calcium): ≤ 5 ppb
LC-MS Positive Mode (tested with Reserpine): Suitable for LC-MS analysis Fe (Iron): ≤ 5 ppb
LC-MS Negative Mode (tested with Reserpine): Suitable for LC-MS analysis K (Potassium): ≤ 5 ppb
Gradient Suitability (at 210 nm): ≤ 1.0 mAU Mg (Magnesium): ≤ 5 ppb
Gradient Suitability (at 254 nm): ≤ 0.2 mAU Na (Sodium): ≤ 25 ppb
Residue on Evaporation: ≤ 1 ppm Acidity: ≤ 1 µeq/g
Water: ≤ 0.01% Alkalinity: ≤ 0.2 µeq/g
Fluorescence (as quinine at 245 nm): ≤ 0.3 ppb  
Fluorescence (as quinine at 365 nm): ≤ 0.3 ppb  

 

LC-MS Methanol Specifications:

Identity (by Infrared Spectroscopy): Identity confirmed Al (Aluminium): ≤ 5 ppb
Purity (by Gas Chromatography): ≥ 99.9% Ca (Calcium): ≤ 5 ppb
LC-MS Positive Mode (tested with Reserpine): Suitable for LC-MS analysis Fe (Iron): ≤ 5 ppb
LC-MS Negative Mode (tested with Reserpine): Suitable for LC-MS analysis K (Potassium): ≤ 5 ppb
Gradient Suitability (at 230 nm): ≤ 2.0 mAU Mg (Magnesium): ≤ 5 ppb
Gradient Suitability (at 254 nm): ≤ 0.5 mAU Na (Sodium): ≤ 25 ppb
Residue on Evaporation: ≤ 1 ppm Acidity: ≤ 1 µeq/g
Water: ≤ 0.01% Alkalinity: ≤ 0.2 µeq/g
Fluorescence (as quinine at 245 nm): ≤ 0.5 ppb  
Fluorescence (as quinine at 365 nm): ≤ 0.5 ppb  

 

LC-MS Water Specifications:

LC-MS Positive Mode (tested with Reserpine): Suitable for LC-MS analysis Al (Aluminium): ≤ 5 ppb
LC-MS Negative Mode (tested with Reserpine): Suitable for LC-MS analysis Ca (Calcium): ≤ 5 ppb
Gradient Suitability (at 210 nm): ≤ 2.0 mAU Fe (Iron): ≤ 5 ppb
Gradient Suitability (at 254 nm): ≤ 0.5 mAU K (Potassium): ≤ 5 ppb
Residue on Evaporation: ≤ 1 ppm Mg (Magnesium): ≤ 10 ppb
Fluorescence (as quinine at 245 nm): ≤ 0.5 ppb Na (Sodium): ≤ 50 ppb
Fluorescence (as quinine at 365 nm): ≤ 0.5 ppb  

Literature

Agilent InfinityLab solvents for HPLC and LC/MS
Agilent InfinityLab LC-MS Solvents