The Agilent Altura Poroshell 120 PFAS HPLC columns are designed to address the analytical challenges associated with per- and polyfluoroalkyl substances (PFAS), particularly ultra-short-chain species that are difficult to retain using conventional reversed phase approaches. Incorporating Poroshell 120 mixed-mode C18 superficially porous particles with advanced Ultra Inert hardware, these columns minimise metal interactions and deliver improved peak symmetry, heightened sensitivity, and consistent reproducibility. The result is reliable retention and separation of highly polar, anionic PFAS, including C1–C3 compounds such as TFA, alongside effective elution of longer-chain analytes up to C18 within a single analytical method.

Designed for compatibility with LC–MS workflows and evolving environmental testing requirements, Altura Poroshell 120 PFAS columns support streamlined dilute-and-shoot methodologies, enabling direct injection of clean aqueous samples without extensive sample preparation. This facilitates reduced consumable use and faster turnaround times while maintaining robust quantitation and low carryover. The inclusion of a dedicated Poroshell PFAS delay column further enhances analytical confidence by trapping background contamination from system components, ensuring accurate trace-level detection. These features enable laboratories to standardise PFAS workflows, extend analytical coverage across C1–C18 species, and implement reproducible, high-performance methods for drinking water and environmental analysis.