Regis ChiroSil Crown Ether Chiral Columns

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ChiroSil Crown Ether Chiral Columns from Regis
ChiroSil columns are ideal for the separation of chiral compounds containing primary amines and natural and unnatural amino acids and their derivatives. Chirosil/ME RCA (+) and SCA (-) have (+) or (-)-(18-Crown-6)-tetracarboxylic acid as a chiral selector, which is covalently bonded to the silica support, ensuring excellent column durability. The ChiroSil CSP is compatible with both normal phase and reversed-phase HPLC and is available in both analytical and preparative dimensions. It is also available in both enantiomeric forms (RCA (+) or SCA (-)), which allows for inversion of peak elution order, which can be beneficial for preparative separations.
In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column.
In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME, while capacity factors on ChiroSil ME are greater than on ChiroSil.
Regis ChiroSil Crown Ether chiral columns are ideal for the separation of chiral compounds containing primary amines and natural and unnatural amino acids and their derivatives. Chirosil/ME RCA (+) and SCA (-) have (+) or (-)-(18-Crown-6)-tetracarboxylic acid as a chiral selector, which is covalently bonded to the silica support, ensuring excellent column durability.
The ChiroSil CSP is compatible with both normal phase and reversed-phase HPLC and is available in both analytical and preparative dimensions. It is also available in both enantiomeric forms (RCA (+) or SCA (-)), which allows for inversion of peak elution order, which can be beneficial for preparative separations.
In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column. In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME, while capacity factors on ChiroSil ME are greater than on ChiroSil.
Features
- ChiroSil RCA(+) and SCA(-) are proven chiral stationary phases for the separation of amino acids and compounds containing primary amines
- Chirosil ME is for applications where greater retention and capacity are needed
- Excellent durability due to covalent bonding
- Available in both enantiomeric forms [RCA(+) and SCA(-)], which allows for the inversion of peak elution order
- Columns are stable to 5,000 psi (~345 bar)
- Columns are available in 5 and 10 µm particle sizes and analytical and preparative dimensions
Specifications
Column | Selector/Phase Type |
ChiroSil RCA(+) | (+)-(18-Crown-6)-tetracarboxylic acid |
ChiroSil SCA(-) | (-)-(18-Crown-6)-tetracarboxylic acid |
ChiroSil ME RCA(+) | (+)-(18-Crown-6)-tetracarboxylic acid |
ChiroSil ME SCA(-) | (-)-(18-Crown-6)-tetracarboxylic acid |