Thermo Scientific MAbPac HIC Columns
All pictures shown are for illustration purpose only. Actual product may vary.
The Thermo Scientific MAbPac HIC column family is designed for separation of monoclonal antibodies and related biologics by hydrophobic interaction chromatography (HIC). These columns are designed to address the separation challenges as the result of heterogeneity, complexity, and diversity of mAbs and related biologics.
The MAbPac HIC-10 is the column of choice for intact mAbs/proteins and mAb aggregates while the MAbPac HIC-20 is suited to resolve mAb fragments, oxidized mAbs and bispecific mAbs. When it comes to ADCs, MAbPac HIC-Butyl is ideal for cystein-conjugated ADC while MAbPac HIC-10 and MAbPac HIC-20 have proven useful for several cysteine proprietary ADC molecules.
Features
- Advanced column chemistry designed for separating mAbs and related biologics
- Broad selectivity coverage for most challenging separations of mAbs
- Excellent bio-compatibility
- High column efficiency
- Rugged column packing
Specifications
| MAbPac HIC-10 | MAbPac HIC-20 | MAbPac HIC-Butyl | |
| Phase | Proprietary polyamide | Proprietary amide | Butyl |
| Particle Type | Spherical, high purity silica | Spherical, high purity silica | Hydrophilic polymer |
| Particle Size | 5 µm | 5 µm | 5 µm |
| Pore Size | 1000 Å | 1000 Å | Non-porous |
| pH Range | 2 - 8 | 2 - 9 | 2 - 12 |
| Maximum Temperature | 60°C | 60°C | 60°C |
| Aqueous Compatibility | 0 - 100% | 0 - 100% | 0 - 100% |
| Organic Compatibility | 0 - 100% | 0 - 100% | 0 - 50% |
