puriFlash Ion-Exchange Flash Columns from Advion-Interchim Scientific
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The puriFlash SAX (Strong Anion Exchange) and puriFlash SCX (Strong Cation Exchange) ion-exchange flash columns from Advion-Interchim Scientific are designed for high-efficiency purification of ionisable compounds via anion and cation exchange mechanisms. With optimised surface chemistries, they deliver reliable, reproducible flash purifications.
puriFlash SAX columns, functionalised with quaternary amines, enable effective retention and purification of weakly acidic analytes carrying negative charges. Typical targets include nucleotides, nucleosides, and organic acids. The media offers an ion-exchange capacity of 0.3 meq/g, a surface area of 500 m²/g, a 60 Å pore size, and a uniform 50 µm particle size, ensuring consistent and robust performance.
puriFlash SCX columns incorporate sulphonic acid groups for the purification of weakly basic molecules with positive charges, such as peptides, alkaloids, and basic pharmaceutical intermediates. The SCX phase features an ion-exchange capacity of 0.3 meq/g, a surface area of 400 m²/g, a 100 Å pore size, and a 50 µm particle size, providing high binding efficiency and reproducibility.
Features
- Strong ion exchangers: SAX (quaternary amines) for anions; SCX (sulphonic acids) for cations
- Targeted purification: SAX for weak acids (nucleotides, nucleosides, organic acids); SCX for weak bases (peptides, alkaloids)
- Consistent particle size: 50 µm for reproducible flow and sharp separations
- Ion-Exchange capacity: 0.3 meq/g ion-exchange capacity on both phases
- Stable pH range: 1.0 – 7.5 for versatile method conditions
- Reproducible and scalable: Reliable from small-scale to preparative purifications
- Flash system compatible: Optimised for flash chromatography platforms
Specifications
| puriFlash SAX | puriFlash SCX | |
| Mode | Strong Anion Exhange | Strong Cation Exchange |
| Particle Type | Spherical | Spherical |
| Particle Size | 50 µm | 50 µm |
| Pore Size | 60 Å | 100 Å |
| Surface Area | 500 m²/g | 400 m²/g |
| Ion-Exchange Capacity | 0.3 meq/g | 0.3 meq/g |
| Endcapped | No | No |
| pH Range | 1.0 - 7.5 | 1.0 - 7.5 |
