Biochromatography HPLC Columns

Biochromatography columns are critical tools for biopharma research and manufacturing, enabling reliable separations across a wide range of biomolecules. Whether you are analysing amino acids, peptides, proteins, oligonucleotides, or glycans, our portfolio of bio columns supports key techniques including reversed phase, HILIC, ion exchange, size exclusion, hydrophobic interaction, and affinity chromatography. 

Designed with advanced stationary phases to minimise secondary interactions, these HPLC columns deliver the resolution, reproducibility, and robustness needed for accurate characterisation of biologics and biosimilars. From discovery to process development and quality control, our biochromatography solutions provide the performance required to monitor critical quality attributes (CQAs) with confidence. 

HPLC is a widely used technique for the analysis of biomolecules, including peptides and proteins, oligonucelotides, vaccines, amino acids and DNA / RNA. We offer columns from the world’s leading manufacturers for the following analysis types;

• Reversed Phase columns for peptide sequencing or the analysis of post translational modifications of in-tact proteins or protein fragments
• Hydrophilic Interaction Chromatography (HILIC) columns for the analysis and characterisation of protein glycoforms
• Protein affinity columns for Titre analysis during manufacture or process development
• Ion exchange columns for charged variant analysis
• Size exclusion columns for aggregate, fragment clips and truncation analysis
• Hydrohobic Interaction Chromatography for Intact protein analysis and Drug to Antibody Ratio analysis
• Amino Acid analysis columns
• Oligonucleotide analysis columns

Our vast column range, from premium manufacturers such as Agilent, Advanced Materials Technology, and YMC includes columns designed for UHPLC and using world class substrates to minimise unwanted secondary interactions