Tosoh Bioscience LenS3 MALS
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Detectors
Stand-alone detectors for HPLC operate independently of integrated chromatographic systems, providing flexible detection solutions for a wide range of analytical applications. These instruments can be coupled to any compatible HPLC or UHPLC system and are often used to upgrade existing setups or support specialised detection methods. Offering dedicated control interfaces and versatile connectivity, stand-alone detectors enable precise measurement across diverse analyte types and separation conditions.
MULTI-ANGLE LIGHT SCATTERING (MALS) DETECTOR
Multi-Angle Light Scattering (MALS) detectors are analytical instruments used to determine the absolute molecular weight and size of macromolecules in solution without reliance on calibration standards. By measuring the intensity of scattered light at multiple angles, MALS provides direct insight into molecular properties such as the radius of gyration, conformation, and aggregation state. When coupled with chromatographic separation techniques such as GPC/SEC, MALS enables detailed characterisation of polymers, proteins, and other complex biomolecules with high precision and reproducibility.
EVAPORATIVE LIGHT SCATTERING DETECTOR (ELSD)
Evaporative Light Scattering Detectors (ELSDs) are universal detectors used in liquid chromatography for the analysis of non-volatile and semi-volatile compounds. The detector operates by nebulising the eluent, evaporating the mobile phase, and measuring the intensity of light scattered by the remaining analyte particles. ELSDs provide a mass-sensitive response that is independent of the compound’s optical properties, making them particularly suitable for detecting analytes lacking chromophores, such as lipids, sugars, and polymers. When used with HPLC or UHPLC systems, ELSD offers reliable quantification and broad applicability across diverse analytical fields.
ELECTROCHEMICAL DETECTOR (ECD)
Electrochemical Detectors (ECDs) are highly sensitive analytical instruments used in liquid chromatography to detect compounds that can undergo oxidation or reduction at an electrode surface. The detector measures the electrical current generated by these redox reactions, which is directly proportional to the analyte concentration. ECDs provide excellent selectivity and sensitivity, particularly for electroactive species such as neurotransmitters, pharmaceuticals, and antioxidants. When coupled with HPLC systems, they enable precise quantitative analysis at trace levels, making them valuable tools in biochemical, environmental, and pharmaceutical research.
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Our knowledgeable team can help you choose the right HPLC column for your method and instrumentation. We can also help you with HPLC column care and maintenance so that you get the best value out of your column while reducing repeat analyses.