Altura HPLC columns from Agilent redefine bio-inert liquid chromatography through advanced Ultra Inert coating technology applied to stainless steel hardware. This proprietary treatment eliminates active metal sites to prevent adsorption and unwanted interactions that can distort peak shape and reduce recovery. Altura columns deliver sharper peaks, improved sensitivity, and outstanding reproducibility for metal-sensitive analytes. With rapid equilibration, long lifetime, and stable performance, they are ideal for high-precision analytical and LC-MS workflows.

The Altura Peptide Plus column is designed for peptide therapeutic impurity analysis, including GLP-1 and insulin characterisation. It features a reversed phase, superficially porous 2.7 µm particle and a C18 stationary phase with a charged surface for superior selectivity and resolution. This column efficiently separates peptide impurities such as amino acid insertions, deletions, deamidation, oxidation, and water-loss variants. Optimised for LC-MS workflows using formic acid, it ensures symmetrical peaks, consistent retention, and precise detection of low-level post-translational modifications (PTMs). The bio-inert hardware minimises adsorption of acidic or phosphorylated peptides, enhancing recovery, sensitivity, and reproducibility – making it an ideal choice for comprehensive peptide mapping and impurity profiling.