Advion-Interchim puriFlash XS 530

The puriFlash XS 530 is a compact, semi-preparative flash chromatography system designed for high-throughput laboratories. With a flow rate of 300 mL/min and maximum pressure of 30 bar, it supports both flash and reverse-phase separations using columns from 20 to 30 mm ID, down to 10 μm particle size – enabling high-resolution, time-efficient purifications.

Engineered for efficiency, the system reduces solvent use through Ultra Performance Flash Purification (UPFP), supporting greener workflows and faster evaporation. Its UV detector operates across 200–400 nm with high sensitivity (1 mAU), enabling reliable detection of low-concentration or weakly absorbing compounds, with recovery rates exceeding 95%.

The XS 530 features a 15-inch touchscreen with ClearPeak Genius software for intuitive method setup, TLC/HPLC-based method generation, and remote monitoring. Built-in fume containment allows safe benchtop use outside traditional hoods. Compact yet robust, the system is ideal for continuous, unattended operation in demanding lab environments.

Features

  • ClearPeak Software Control – Full system operation with intuitive interface for method development and monitoring
  • Smartphone App Compatibility – Supports TLC to Flash & Prep app for direct method transfer from TLC plates
  • 15" Touchscreen & Controller – User-friendly interface for real-time control and remote access
  • Multi-Wavelength UV Detection – 200–400 nm range with collection mode scan for enhanced compound detection
  • Column Compatibility – Supports preparative columns (20 mm and 30 mm ID) and flash columns (F0004 to F3000 series)
  • High-Capacity Collection – Two long racks accommodating up to 112 tubes (18 × 150 mm)
  • High Flow Rate – Up to 300 mL/min for efficient processing
  • Maximum Pressure – Operates at up to 30 bar for semi-preparative applications

Specifications

  puriFlash XS 530
Pump  
Flow rate 300 mL/min
Max pressure 30 bar
Quaternary gradient yes
Air purge yes
Washing discs no
Pump washing discs (pack) no
   
Detector  
UV: 200 - 400 nm multi wavelength & scan collection yes
UV: 200 - 800 nm multi wavelength & scan collection pack-UVextended
Spectral view and purity confirmation yes
iELSD Detection (pack) pack-iELSD
   
Injection  
4 port electrical valve pack 4-ways electric valve
6 port electrical valve with loop no
6 port + 10 port electrical valves with loop no
Injection mode: liquid - dry-load yes
   
Column Selection Valve  
6 port electrical valve no
   
System Optimisation  
Tubing after pump 1/8" x 1.6 mm ID
Flow cell: optical length/volume 0.1 mm/40 µL
   
Column Holder  
Integrated yes
Pre-column holder no
   
Fraction Collector  
Reglular collector 2 long racks
112 tubes 18 x 150 mm
   
Unit Control  
Touch screen 15" yes
USB 6
RJ45 yes
   
Safety  
Leak detection (pump, FC, iELSD, holders) no
Solvent tray with drainage system yes
Collector with drainage system yes
Solvent and waste level monitoring no
RFID no
Fume enclosure yes
   
Size Width: 35.5 cm
Depth: 47 cm
Height: 80 cm

Literature

The essential systems and consumables for purification, evaporation, and mass spectrometry

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