puriFlash Prep HPLC Columns from Advion-Interchim Scientific

Advion-Interchim Scientific puriFlash Prep HPLC Columns

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puriFlash Prep HPLC columns from Advion-Interchim Scientific are designed for high-loadability purification and routine analysis of small organic molecules, supporting efficient method development and seamless transfer to preparative-scale workflows in pharmaceutical applications. With internal diameters ranging from 4.6 mm to 50 mm and particle sizes of 5 µm, 10 µm and 15 µm, the series offers straightforward scalability from analytical through to semi-preparative formats. A broad selection of reversed phase and normal phase chemistries provides flexibility for diverse compounds and purification strategies.

puriFlash Phase Options Tailored for Small Molecule Purification

puriFlash C18-AQ: Features a hydrophilic bonding chemistry that enables gradients starting at 100% water for purification of mid- to non-polar compounds.
puriFlash C18-HP: A versatile C18 phase ideal for routine reversed phase purification across a wide range of pharmaceutical small molecules.
puriFlash C18-XS: Utilises a proprietary multi-step process to create a fully endcapped phase stable up to pH 10, providing excellent performance for the purification of basic drugs.
puriFlash Diol: A diol-functionalised phase that produces a neutral silica surface, enhancing the separation of basic compounds in normal phase mode compared with conventional silica materials.
puriFlash NH2: An amino-functional phase that can be used in reversed phase, normal phase or ion exchange methods.
puriFlash RP-AQ: A reversed phase material allowing gradients from 100% water and designed for high- and mid-polar compounds; compared with standard C18, it provides earlier elution at the start of the gradient for improved workflow efficiency.
puriFlash SI-HP: A high-purity silica phase suitable for non-ionic, polar organic compounds, offering reliable performance for classical normal phase separations.

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		Part Number	Product Description	Price	Qty

Features

High Loadability – Optimised for routine analysis and preparative purification of small organic molecules
Reversed Phase and Normal Phase Options – Wide selection of chemistries to match compound polarity and method requirements
Scalable Formats – Available from 4.6 to 50 mm ID with 5 µm, 10 µm or 15 µm particles for easy transfer from analytical to semi-prep scale
Reproducible Performance – Developed for consistent retention, resolution, and peak shape across purification campaigns
Pharma-Ready Design – Developed to meet the needs of medicinal chemistry, process development, and routine purification workflows
Extended Column Lifetime – Guard cartridges, when used with the appropriate guard holder, provide extra protection to maximise the life of your prep column

Specification

	C18-HP	C18-XS	C18-AQ	RP-AQ	SI-HP	Diol	NH2
Phase	C18	C18	C18	RP-alkyl	Silica	Diol	Amino
Mode	Reversed Phase	Reversed Phase	Reversed Phase	Reversed Phase	Normal Phase	Normal Phase	Reverse Phase / Normal Phase / Ion Exchange
Particle Type	Fully Porous	Fully Porous	Fully Porous	Fully Porous	Fully Porous	Fully Porous	Fully Porous
Particle Size	5 µm, 10 µm, 15 µm	5 µm, 10 µm, 15 µm	5 µm, 10 µm, 15 µm	15 µm	5 µm, 10 µm, 15 µm	10 µm, 15 µm	5 µm, 10 µm, 15 µm
Pore Size	100 Å	100 Å	100 Å	60 Å	60 Å	60 Å	100 Å
Surface Area	300 m2/g	300 m2/g	300 m2/g	500 m2/g	500 m2/g	500 m2/g	300 m2/g
Carbon Load	16.5%	17.0%	14.0%	6.0%	-	-	4.0%
Endcapped	One-step	Multi-step	Mixed	Mixed	-	No	One-step
pH Range	1.5 - 7.5	1.0 - 10	2.0 - 7.5	2.0 - 7.5	1.5 - 6.5	1.5 - 6.5	2.0 - 6.5
USP Designation	L1	L1	L1	L7	L3	L20	L8